Dynamics of microRNA regulation

microRNAs silence target gene expression by binding to the 3`UTRs of target mRNAs. microRNAs play important roles in developmental and oncogenic pathways that are critical for cell fate decisions. However, it remains unclear whether microRNAs provide distinct functional capabilities relative to proteins as regulators of these processes. We combine single-cell measurements, time-lapse microscopy, and animal models to address this question.