A gut-brain neural circuit for nutrient sensory transduction.

TitleA gut-brain neural circuit for nutrient sensory transduction.
Publication TypeJournal Article
Year of Publication2018
AuthorsKaelberer, MM, KL Buchanan, ME Klein, BB Barth, MM Montoya, X Shen, and DV Bohórquez
JournalScience
Volume361
Issue6408
Date Published09/2018
Abstract

The brain is thought to sense gut stimuli only via the passive release of hormones. This is because no connection has been described between the vagus and the putative gut epithelial sensor cell-the enteroendocrine cell. However, these electrically excitable cells contain several features of epithelial transducers. Using a mouse model, we found that enteroendocrine cells synapse with vagal neurons to transduce gut luminal signals in milliseconds by using glutamate as a neurotransmitter. These synaptically connected enteroendocrine cells are referred to henceforth as neuropod cells. The neuroepithelial circuit they form connects the intestinal lumen to the brainstem in one synapse, opening a physical conduit for the brain to sense gut stimuli with the temporal precision and topographical resolution of a synapse.

DOI10.1126/science.aat5236
Short TitleScience