A bio-inspired spatial patterning circuit.

TitleA bio-inspired spatial patterning circuit.
Publication TypeJournal Article
Year of Publication2014
AuthorsChen, K-Y, DJ Joe, JB Shealy, BR Land, and X Shen
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2014
Start Page86
Pagination86 - 89
Date Published01/2014
Abstract

Lateral Inhibition (LI) is a widely conserved patterning mechanism in biological systems across species. Distinct from better-known Turing patterns, LI depend on cell-cell contact rather than diffusion. We built an in silico genetic circuit model to analyze the dynamic properties of LI. The model revealed that LI amplifies differences between neighboring cells to push them into opposite states, hence forming stable 2-D patterns. Inspired by this insight, we designed and implemented an electronic circuit that recapitulates LI patterning dynamics. This biomimetic system serve as a physical model to elucidate the design principle of generating robust patterning through spatial feedback, regardless of the underlying devices being biological or electrical.

DOI10.1109/embc.2014.6943535
Short TitleAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings