|Title||Asymmetric division: An antitumor player?|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||L Wang, P Bu, and X Shen|
|Journal||Molecular & cellular oncology|
miR-34a-mediated asymmetric cell division reins in excessive stem cell expansion during tissue regeneration in the intestine and colon. Loss of miR-34a switches asymmetric division to symmetric division and enhances stem cell proliferation. Asymmetric division also occurs in the early stages of colon cancer stem cells. Mechanistically, miR-34a, Numb, and Notch form a feed-forward loop that specifies cell fate when stem cells divide.
|Short Title||Molecular & cellular oncology|