Asymmetric division: An antitumor player?

TitleAsymmetric division: An antitumor player?
Publication TypeJournal Article
Year of Publication2016
AuthorsWang, L, Bu, P, and Shen, X
JournalMolecular & cellular oncology
Volume3
Issue4
Start Pagee1164279
Date Published07/2016
Abstract

miR-34a-mediated asymmetric cell division reins in excessive stem cell expansion during tissue regeneration in the intestine and colon. Loss of miR-34a switches asymmetric division to symmetric division and enhances stem cell proliferation. Asymmetric division also occurs in the early stages of colon cancer stem cells. Mechanistically, miR-34a, Numb, and Notch form a feed-forward loop that specifies cell fate when stem cells divide.

DOI10.1080/23723556.2016.1164279
Short TitleMolecular & cellular oncology